CB1 receptors are located throughout the brain and central nervous system, as well as in the kidneys, liver, lungs, digestive tract, and even the eyes.
CB2 receptors are primarily found in white blood cells, the peripheral organs, in particular tissues associated with the immune system including the tonsils, thymus, spleen, gastrointestinal system and bone marrow.
The ESC plays a very important role in regulating our physiological functions, many of which relate to stress-recovery systems, among other functions. The endocannabinoid system is involved in modulating the immune and inflammatory responses and regulate appetite, anxiety, sleep, mood control, reproduction & fertility, pleasure & reward, pain, memory and temperature regulation. It also influences the cardiovascular and respiratory systems by controlling heart rate, blood pressure, and bronchial functions.
When our ECS becomes out of balance (no longer in homeostasis) all kinds of conditions can arrises, such as increased risk of heart disease, auto immune disorders, obesity and diabetes, crohn’s disease, fibromyalgia and irritable bowel syndrome. “Clinical Endocannabinoid Deficiency” is the ECS term when the body is no longer producing its own endocannabinoids or self regulating, one becomes much more susceptible to a wide variety of illness and disease.
The good news is that there are ways of treating Clinical Endocannabinoid Deficiency. Firstly one needs to look at their diet as studies have shown that the increased omega-3 levels from fish oil consumption causes significant changes and synergy within the endocannabinoid system. Another major cause of deficiency is stress, so finding ways to de-stress such as walks in nature, creating quality time with family and friends, exercising, meditation and yoga will have a beneficial impact.
The most effective and direct way to bringing the endocannabinoid system back into homeostasis is by supplementing your diet with plant based CBD (cannabinoids). It increases the amount of endocannabinoids in your system and stops the enzyme FAAH from breaking down all of the anandamide thereby making more of it available for use by your cells. Our CBD is produced using hemp extracted to be within world wide regulation of 0.2% THC.
CBD is currently legal in Ireland and across most of Europe and has been put forward within The Medicinal Cannabis Bill in Ireland. It looks as if CBD will be regulated in the future as a medicinal supplement by HPRA (Health Products Regulatory Authority), and this something we very much welcome.